Products built by scientists for scientists

We design all specimen collections, processing workflows and data packages with oncology developers in mind.

NGS-screened tissue blocks & sets

Biomarker-screened, characterized specimens with extra data provided. FFPE blocks are sequenced to determine the genomic alterations present. Data provided in an XLSX format, other formats and PDF genomic reports available upon request.

Details

These samples can include:

Common pathogenic or presumed pathogenic variants (e.g., p53, APC)
Variants prevalent in 20-50% of cancers (e.g., EGFR, KRAS, PIK3CA)
Highly mutated and rare variants and fusions (e.g., MSI high, TMB high, ALK fusion)

Reach out to us for more detailed information on pricing thresholds and how we do our data analysis.

View inventory

Matched sets

Matched sets of plasma and buffy coat from healthy and oncology donors. Tumor and normal tissue are available as an add-on for most cases.

Details

Sets include a combination of any of the following specimen types:

High-quality FFPE tissue
Frozen bone marrow for heme malignancies
Double-spun Streck or EDTA plasma and buffy coat

Exact details about our specimen sets (ie. tissue sizes, plasma volumes) are provided in our live inventory.

Tissue blocks

We offer a variety of tissue-based products, including:

Tumor tissue blocks: from the majority of common cancer indications
Preferred normal tissue blocks: adrenal gland, skin, and other sites most commonly used for control tissue in oncology development
Details

To be qualified for our inventory, a block must have:

5mm2 tumor area or larger
20% or more tumor inside the designated tumor area
50% or less necrosis inside the designated tumor area
Block thickness of 1mm or more

Blood products

Individual plasma and/or buffy coat aliquots from healthy and oncology donors.

Details

To be qualified for our inventory, plasma and buffy coat must be:

Collected in EDTA or Streck tubes
Double-spun, with a hemolysis score of less than 2

Exact volumes for the plasma and buffy coat included in each blood product set are provided in our live inventory.

Additional services

We offer a variety of add-on services, so specimens are delivered to your lab in the exact format you want them. Hello, plug-and-play experience!

Microtomy services

We know that not all labs have a team of histologists ready for action. Don’t let that stop you from getting the tissues you need. From unstained slides, to tissue curls at any thickness - we’ve got you covered!

Imaging services

Are you a pathology AI developer? Or, maybe a picky scientist that likes to see the details of each tissue you bring into your lab? Whole slide imaging is available for any project.

Nucleic acid extraction

Want to skip all of the pre-analytics and get right to library prep? Extraction services are available - just ask! Whether it's DNA and RNA on tissue or cfDNA for plasma, our molecular team is ready for action.

In our pipeline

We’re working on some exciting new offerings! While we wait for wider release, we are also currently piloting these products with select partners. Want to be a part of our pilot program? Get in touch at hello@referencemedicine.com!

Matched frozen tissue

Matched fluids, FFPE blocks, and frozen tissue across a variety of cancer types are currently being offered in limited quantities!

Unless otherwise specified, tissue is snap-frozen at -80C.

Reach out to find out what frozen tissue we have avaliable!

Longitudinal collections

2 - 4 timepoint longitudinal collections for colorectal, lung, and breast cancer.


Timepoint 1: pre-surgery fluid collection (plasma & buffy) with remnant tissue from resection surgery.

Timepoint 2: fluid-only collection (plasma & buffy) at 4-6 weeks post-surgery.

Timepoint 3+: fluid-only collection at each follow-up appointment (plasma & buffy).

New matched sample types

Are you building the next non-invasive diagnostic for a GI or Urinary Tract Tumor?

We will soon be ready to help!

Matched stool (with FFPE, plasma and buffy coat) and matched urine (with the same) will soon be available.

Send us your request for more information!

Have a special request? Tell us about it.
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